Men and women who have been in prison are an under-served group with higher rates of all types of cancer. In addition, they have higher rates of several cancer risk factors, such as infectious disease exposure (such as STD and HPV infection) and cigarette smoking, along with poor socio-economic health determinants including poverty, unstable housing, low literacy, and/or low education levels, and mental health and physical disability. Post-release, men and women are often overwhelmed by the complexities of seeking and receiving health care in the community. Receiving primary care, including cancer screening and early detection, can become a “back-burner” issue, coming well after housing, parole, financial, and family responsibilities. Another significant barrier to accessing care and early screening stems from the lack of trust between this population and service providers, including healthcare practitioners.